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Reticulon-2RTN2Homo sapiens (Human)-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveliFunctioniGO - Biological processiNames & TaxonomyiProtein namesiRecommended name:Reticulon-2Alternative name(s):Neuroendocrine-specific protein-like 1Short name: NSP-like protein 1Neuroendocrine-specific protein-like IShort name: NSP-like protein IShort name: NSPLIGene namesiName:Synonyms:NSPL1OrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome 19 Organism-specific databasesEuPathDBi HGNCi RTN2. MIMi gene. Subcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoskeleton
Peroxisome
Golgi apparatus
Mitochondrion
Manual annotation
Automatic computational assertionGraphics by Christian S Source: TopologyFeature keyPosition(s)DescriptionActionsGraphical viewLengthTransmembraneiHelical 21TransmembraneiHelical 21Keywords - Cellular componenti, Pathology & BiotechiInvolvement in diseaseiThe disease is caused by mutations affecting the gene represented in this entry.Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.Feature keyPosition(s)DescriptionActionsGraphical viewLengthNatural variantiVAR_067562 in SPG12. Manual assertion based on experiment ini"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SPAST, VARIANT SPG12 PHE-367.Corresponds to variant .1Keywords - Diseasei, , Organism-specific databasesDisGeNETi MalaCardsi MIMi phenotype. OpenTargetsi Orphaneti Autosomal dominant spastic paraplegia type 12. PharmGKBi Polymorphism and mutation databasesBioMutai PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_Reticulon-2 545Amino acid modificationsFeature keyPosition(s)DescriptionActionsGraphical viewLengthModified residueiPhosphoserineManual assertion inferred from sequence similarity toi1Modified residueiPhosphoserineManual assertion inferred from sequence similarity toi1Modified residueiPhosphoserineManual assertion inferred from sequence similarity toi1Keywords - PTMiProteomic databasesEPDi MaxQBi PaxDbi PeptideAtlasi PRIDEi PTM databasesiPTMneti PhosphoSitePlusi ExpressioniTissue specificityiIsoform
is highly expressed in skeletal muscle.Manual assertion based on experiment ini"cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.", , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.Gene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei HS. Organism-specific databasesHPAi
InteractioniSubunit structureiInteracts with isoform 1 but not isoform 3 of SPAST (PubMed:). Isoform
interacts with TMEM33 (PubMed:).Manual assertion based on experiment ini"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SPAST, VARIANT SPG12 PHE-367."Identification and characterization of TMEM33 as a reticulon-binding protein.", , , , Kobe J. Med. Sci. 60:E57-E65(2014)
[] [] []Cited for: INTERACTION WITH TMEM33.Protein-protein interaction databasesBioGridi 26 interactors.CORUMi IntActi 3 interactors.STRINGi Structurei3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)DescriptionActionsGraphical viewLengthDomainiReticulonManual assertion according to rulesi 201Keywords - Domaini, Phylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Family and domain databasesInterProi Reticulon. Pfami Reticulon. 1 hit. PROSITEi RETICULON. 1 hit. Sequences (3)iSequence statusi: Complete.This entry describes 3 isoformsi produced by alternative splicing and alternative initiation.
(identifier: O75298-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE
100TTSQDWGTPR ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH
150PQPSLGDSLE SIPSLSQSPE PGRRGDPDTA PPSERPLEDL RLRLDHLGWV
200ARGTGSGEDS STSSSTPLED EEPQEPNRLE TGEAGEELDL RLRLAQPSSP
250EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE KQWGPLEREP
300VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW
350TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY
400WKDTRTSGVV FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV
450LQAVHRGDGA NPFQAYLDVD LTLTREQTER LSHQITSRVV SAATQLRHFF
500LVEDLVDSLK LALLFYILTF VGAIFNGLTL LILGVIGLFT IPLLYRQHQA
540 QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS KAKAE
54559,264November 1, 1998 - v1Checksum:i971FD2F909E1E9E6BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: O75298-2)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.>>47251,429Checksum:iE6DB263BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: O75298-3)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.Note: Produced by alternative initiation at Met-341 of isoform .>>20522,316Checksum:iFF788CF4174074FFBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterNatural variantFeature keyPosition(s)DescriptionActionsGraphical viewLengthNatural variantiVAR_067562 in SPG12. Manual assertion based on experiment ini"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SPAST, VARIANT SPG12 PHE-367.Corresponds to variant .1Natural variantiVAR_053632. Corresponds to variant .1Alternative sequenceFeature keyPosition(s)DescriptionActionsGraphical viewLengthAlternative sequenceiVSP_018870Missing
in isoform .
340Alternative sequenceiVSP_005649Missing
in isoform . Manual assertion based on opinion ini"Molecular cloning of a novel mouse gene with predominant muscle and neural expression.", , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF
(ISOFORM RTN2-B). 73Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .CCDSi
[]UniGenei Genome annotation databasesEnsembli; ; .
[]GeneIDi KEGGi UCSCi human.
[]Keywords - Coding sequence diversityi, , Similar proteinsi mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .CCDSi
[]UniGenei 3D structure databasesProteinModelPortali SMRi ModBaseiMobiDBiProtein-protein interaction databasesBioGridi 26 interactors.CORUMi IntActi 3 interactors.STRINGi PTM databasesiPTMneti PhosphoSitePlusi Polymorphism and mutation databasesBioMutai Proteomic databasesEPDi MaxQBi PaxDbi PeptideAtlasi PRIDEi Protocols and materials databasesStructural Biology KnowledgebaseGenome annotation databasesEnsembli; ; .
[]GeneIDi KEGGi UCSCi human.
[]Organism-specific databasesCTDi DisGeNETi EuPathDBi GeneCardsi HGNCi RTN2. HPAi
MalaCardsi MIMi gene.
phenotype. neXtProti OpenTargetsi Orphaneti Autosomal dominant spastic paraplegia type 12. PharmGKBi GenAtlasiPhylogenomic databaseseggNOGi Eukaryota.
LUCA. GeneTreei HOGENOMi HOVERGENi InParanoidi KOi OMAi OrthoDBi PhylomeDBi TreeFami Miscellaneous databasesChiTaRSi human. GeneWikii GenomeRNAii PROi SOURCEiGene expression databasesBgeei CleanExi ExpressionAtlasi baseline and differential. Genevisiblei HS. Family and domain databasesInterProi Reticulon. Pfami Reticulon. 1 hit. PROSITEi RETICULON. 1 hit. ProtoNeti Q7RTN2Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001Last sequence update: November 1, 1998Last modified: September 27, 2017This is version 134 of the entry and version 1 of the sequence. Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi, Documents
Human chromosome 19: entries, gene names and cross-references to MIM
List of human entries with polymorphisms or disease mutations
Index of human polymorphisms and disease mutations
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot您要找的是不是:
n. [化]网状霉素；[医]羟基链霉素
n. 网状组织，网状质；[天]网罟座（南天...
o-A相同的185个氨基酸的N末端
nogo基因发现后，基于序列上的相似性，其所
编码的Nogo蛋白被认为是浆膜蛋白(Reticulon，
Rtn)家族的第四个成员，含有_二个功能尚不清楚的
跨膜区域。令人惊讶的是，由于少突胶质细胞是通
基于2个网页-
网状内皮素
网状内皮素(reticulon,RTN)是保守序列蛋白家族的统称，RTN 4可抑制严重损伤轴索再生。
基于2个网页-
Nogo蛋白属于网状蛋白(Reticulon)家族成员，即Ret-4AeNogo基因编码的三种同分异构蛋白质是同一Nogo基因通过不同的启动子或RNA剪接方式形成的。
基于1个网页-
网状蛋白质家族
氨基酸的保守区
神经内分泌特异性蛋白抗体
Reticulons (RTNs in vertebrates and reticulon-like proteins or RNTls in other eukaryotes) are a group of evolutionary conservative proteins residing predominantly in endoplasmic reticulum, primarily playing a role in promoting membrane curvature . In addition reticulons may play a role in nuclear pore complex formation, vesicle formation, and other processes yet to be defined.
以上来源于:
Promise me a date if I just deliver these 60 tonnes of nanotech to Reticulon Blarg, three solar systems away, on Twitter.
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感谢您的反馈，我们会尽快进行适当修改！[ri'tikjulin]
n. 网状霉素；羟基链霉素
物科技有限公司,（供应）GMS80025.1
石蜡切片网硬蛋白（RETICULIN）染色试剂盒价格,GMS80025.1
石蜡切片网硬蛋白（RETICULIN）染色试剂盒参数,GMS80025.1
石蜡切片网硬蛋白（RETICULIN）染色试剂...
基于349个网页-
在线英语词典,英文翻译,科技词典,专业词典,在线词... ... 网织红细胞，网状细胞：reticulocyte (Rct) 网硬蛋白;网硬素：reticulin 网托盘：wire tray ...
基于89个网页-
...、去氢紫堇达明碱等。除生物碱外，延胡索中尚含有大量淀粉，少量黏液质、树脂、挥发油，另含无机微量元素。还含有多糖、羟链霉素(reticulin)、豆甾醇、谷甾醇、油酸、亚油酸、亚麻酸、延胡索酸、10-二十九碳醇等。
基于16个网页-
第二篇 食品加工的原料和材料 ... 弹性蛋白（elastin） 网状蛋白（reticulin） （1）蓄积脂肪(depots fats) ...
基于12个网页-
网状纤维染色
网硬蛋白纤维化
网硬蛋白纤维
水解网硬蛋白
人网硬蛋白抗体
网硬蛋白纤维
更多收起网络短语
网硬蛋白;网菌素
羟基链霉素
&2,447,543篇论文数据，部分数据来源于
[ri'tikjulin]
【生物化学】网硬蛋白
以上来源于：《21世纪大英汉词典》
Objective:To explore the value of bone marrow biopsy in diagnosing acute and chronic leukemia with reticulin myelofibrosis.
目的：评估骨髓活检在急、慢性白血病继发网硬蛋白纤维化时的诊断价值。
Objective To determine the distribution of reticulin fibre and megakaryocyte in bone marrow biopsy(Trephine biopsy)of chronic myelogenous leukemia (CML).
目的为了解慢性粒细胞白血病（CML）骨髓中巨核细胞和网状纤维的增生情况及其关系。
Results Gantaikang could effectively counteract the increase of HA, LN and PCIII level in serum, and attenuate hepatic collagen and reticulin proliferation induced by porcine serum in rats.
结果甘泰康可有效对抗猪血清所致大鼠血清HA、LN、PCIII含量升高，有效对抗猪血清所致大鼠肝组织内胶原纤维、网状纤维增生。
$firstVoiceSent
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感谢您的反馈，我们会尽快进行适当修改！细胞库/细胞培养
ELISA试剂盒
实验室仪器/设备
原辅料包材
体外检测试剂
&&(S)-Reticuline
(S)-Reticuline
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