是hodgkin s lymphomalymphoma 2，但不能确定是hodgkin s lymphomalymphoma classic 还是subtype，bot

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lymphomagenesis in hodgkin lymphoma论文.pdf8页
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YSCBI-1170;
No. of Seminars in Cancer Biology xxx
xxxCxxx Contents lists available at ScienceDirect Seminars in Cancer Biology j o u r n a l h o me p a ge : w w w. /locate/semcancer
Lymphomagenesis in Hodgkin lymphoma
Eri Matsuki, Anas Younes ?
Lymphoma Service, Memorial Sloan-Kettering Cancer Center, United States
Keywords: Hodgkin lymphoma
accounts for approximately 0.6% of all new cancer cases, 10% of all lymphomas
Classical Hodgkin lymphoma in the USA, leading to an approximate 9000 new cases per year. It is very unique in that the neoplastic
Hodgkin and ReedCSternberg cells Hodgkin and ReedCSternberg
cells of classical HL account for only 1% of the tumor tissue in most
Microenvironment cases, with various
in?ammatory cells including B-cells, T-cells,
mast cells, macrophages, eosinophils,
NF-B neutrophils, and plasma cells comprising the tumor microenvironment.
JAK/STAT Recent research has identi?ed germinal center B-cells to be the cellular origin of HRS cells. Various transcription factor dysregulation in these neoplastic cells that explains for the loss of B-cell phenotype as well as acquisition of survival and anti-apoptotic features of HRS cells has been identi?ed. Aberrant activation of nuclear factor-kappa B
NF-B , Janus
JAK /signal transducer and activator of tran- scription
STAT , and phosphoinositide 3-kinase
pathways play a central role in HL pathogenesis. Both intrinsic genetic
mechanisms as well
as extrinsic signals have been identi?ed to account for the constitutive activation of these pathways. The extrinsic factors that regulate the activation of transcription pathways in HRS cells have also been studied in detail. Cytokines and chemokines produced both by the HRS cells as well as cells of the microen- vironment of HL work in an autocrine and/or paracrine manner to promote survival of H
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